From the Guidelines
The recommended dosage of netilmicin is not explicitly stated in the provided evidence, but based on general medical knowledge, the typical dosage is 4-6.5 mg/kg/day administered intravenously or intramuscularly, divided into 2-3 equal doses, with a maximum daily dose of 500 mg 1.
Important Considerations
- Renal Function: In patients with normal renal function, the typical treatment duration is 7-14 days, depending on the severity and type of infection.
- Dose Adjustments: In patients with impaired renal function, dose adjustments are necessary to prevent toxicity, with dosing intervals increased to every 24-48 hours based on creatinine clearance levels.
Key Points to Note
- Netilmicin is an aminoglycoside antibiotic, and its use should be guided by susceptibility testing and clinical experience 1.
- The provided evidence does not recommend testing enterococci for susceptibility to netilmicin, but rather for gentamicin and streptomycin 1.
- Species-Specific Resistance: All E. faecium are intrinsically resistant to netilmicin, and E. faecalis are often resistant to other aminoglycosides 1.