Clobetasol Propionate Ointment Concentration
Clobetasol propionate ointment is commercially available in the United States exclusively at a 0.05% concentration 1.
Available Formulations and Packaging
The FDA-approved clobetasol propionate ointment USP 0.05% is supplied in tamper-evident tubes in the following sizes 1:
- 15 g (NDC 0168-0162-15)
- 30 g (NDC 0168-0162-30)
- 45 g (NDC 0168-0162-46)
- 60 g (NDC 0168-0162-60)
Clinical Context
While the AAD-NPF guidelines list clobetasol propionate 0.05% as a Class I (superpotent) topical corticosteroid for psoriasis management 2, only the 0.05% concentration is FDA-approved and commercially available in ointment form in the United States. This concentration applies across all vehicle formulations (ointment, cream, gel, spray, foam, lotion, and shampoo) 1, 3.
Important Clinical Caveat
Although research has explored lower concentrations (such as 0.025% cream formulations studied in India) 4, these are not commercially available in the United States. Any prescriptions for clobetasol propionate ointment will be dispensed at the standard 0.05% concentration.
Storage Requirements
Store at controlled room temperature 15°-30°C (59°-86°F). Do not refrigerate 1.