From the Guidelines
Streptococcus salivarius bacteremia treatment should be done with antibiotic therapy for a duration of 4 weeks 1.
Recommended Antibiotics
- Penicillin G: 12-18 million units per day, administered intravenously in divided doses every 4 hours 1
- Ceftriaxone: 2 grams per day, administered intravenously in a single dose 1
- In cases of penicillin allergy, vancomycin may be used as an alternative, with a dose of 30 mg/kg/day administered intravenously in divided doses 1
Special Considerations
- The treatment duration may be extended to 6 weeks in patients with underlying conditions, such as endocarditis or prosthetic valve infection 1
- For patients with penicillin-resistant strains, aminoglycoside treatment must be given for at least 2 weeks and short-term therapy regimens are not recommended 1
- Vancomycin may be preferred in cases of highly resistant isolates (MIC ≥4 mg/L), combined with aminoglycosides 1
From the Research
Antibiotic Treatment Duration for S. salivarius Bacteremia
There are no research papers to assist in answering this question, as the provided study 2 focuses on the colonization of Streptococcus mutans and Lactobacillus in patients with and without cleft lip and/or palate undergoing orthodontic treatment, and does not address the treatment of Streptococcus salivarius (S. salivarius) bacteremia.
- The study 2 is a meta-analysis that evaluates the oral colonization of S. mutans and Lactobacillus in patients with and without cleft lip and palate.
- It does not provide information on the recommended antibiotic treatment duration for S. salivarius bacteremia.
- Therefore, there is no relevant evidence to answer the question about the recommended antibiotic treatment duration for S. salivarius bacteremia based on the provided study 2.