What is the differential diagnosis (DDX) of a skin tag in the anal area?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 2, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Skin Tag in the Anal Area

  • Single most likely diagnosis
    • Anal skin tag: This is the most common and benign cause of a skin tag in the anal area, often resulting from a resolved hemorrhoid or anal fissure.
  • Other Likely diagnoses
    • Hemorrhoid: Although a skin tag can be a residual of a hemorrhoid, an active hemorrhoid can also present with a tag-like appearance.
    • Anal fissure: Similar to hemorrhoids, an anal fissure can cause a skin tag, especially if it has healed and left behind a small piece of skin.
    • Condyloma acuminatum (genital wart): Caused by human papillomavirus (HPV), these can appear as small, skin-tag-like growths in the anal area.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Anal cancer: Although rare, it's crucial to rule out anal cancer, as it can present with a lesion that resembles a skin tag, especially in immunocompromised patients or those with a history of HPV.
    • Melanoma: A rare but potentially deadly skin cancer that can occur in the anal area, presenting as an unusual skin growth.
  • Rare diagnoses
    • Neurofibroma: A rare, benign nerve sheath tumor that can occur in the anal area, presenting as a skin tag or a soft, fleshy growth.
    • Leiomyoma: A rare, benign smooth muscle tumor that can occur in the anal area, presenting as a firm, skin-tag-like growth.
    • Accessory tragus: A rare congenital anomaly where extra skin tags are present, which can occur in the anal area, although this is extremely uncommon.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.