From the Research
Definition and Characteristics of Stercoral Colitis
- Stercoral colitis is not directly mentioned in the provided studies, but diversion colitis, a related condition, is discussed in detail.
- Diversion colitis is characterized by mucosal inflammation in the defunctioned segment of the colon following a colostomy or ileostomy 1.
- The major causes of diversion colitis are an increase in the number of aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon 1.
Treatment Strategies for Diversion Colitis
- Various treatment strategies for diversion colitis have been explored, including SCFAs, 5-aminosalicylic acid enemas, steroid enemas, and irrigation with fibers 1.
- Fecal microbiota transplantation (FMT) has emerged as a promising treatment for diversion colitis, with potential benefits including low medical costs, ease of use, and minimal side effects 1.
- Other treatments, such as sucralfate enemas 2 and somatostatin 3, have also shown therapeutic potential in managing diversion colitis.
Experimental Models of Diversion Colitis
- Experimental models of diversion colitis have been developed in rats 3 and mice 4 to study the pathophysiological mechanisms leading to the development of this disease.
- These models have facilitated the study of the immune system's role and its interaction with the microbiome in the development of diversion colitis 4.