From the Guidelines
The normal albumin level typically ranges from 3.8 to 5.1 g/dL when measured by the bromcresol green (BCG) colorimetric method, which is the most commonly used assay in clinical laboratories. This range is based on the study by the National Kidney Foundation, which reported that the BCG method is rapid, reproducible, and has a low coefficient of variation 1. The BCG method is widely used due to its automation and low cost, although it may underestimate albumin levels in the high normal range and overestimate them below the normal range.
Key Points to Consider
- The normal range for serum albumin can vary depending on the assay used, with the BCG method being the most commonly used 1.
- Other methods, such as nephelometry and electrophoresis, are more specific but are not typically used in clinical laboratories due to their high cost and time-consuming nature 1.
- The bromcresol purple (BCP) colorimetric method is another alternative, but it has been shown to be less reliable than the BCG method, particularly in pediatric patients and those with chronic renal failure 1.
Clinical Implications
- When interpreting albumin levels, it is essential to consider the assay used and its normal range 1.
- Albumin levels can be affected by various factors, including hydration status, recent illness, or inflammation, and should be evaluated in the context of the patient's overall health status.
- Regular monitoring of albumin levels may be recommended for patients with chronic liver or kidney conditions, and the choice of assay should be based on the laboratory's capabilities and the patient's specific needs 1.
From the Research
Normal Albumin Level
The normal albumin level is not explicitly stated in the provided studies. However, some studies provide information on albumin levels in certain contexts:
- A study published in 2015 2 mentions that in elderly patients with a hip fracture, albumin levels below 38 g/L are associated with a higher risk of post-surgery complications.
- Another study published in 2018 3 does not provide a specific normal albumin level, but discusses the importance of albumin in the management of patients with cirrhosis.
- A study from 1988 4 discusses albumin metabolism in the nephrotic syndrome, but does not provide a normal albumin level.
- A 2016 study 5 discusses the structure, functions, and therapeutic implications of albumin in chronic liver disease, but does not provide a normal albumin level.
- A 2020 study 6 discusses the indications of albumin in chronic liver disease, but also does not provide a normal albumin level.
Key Points
- Albumin is an important protein produced by the liver, with various functions including oncotic effects, immunomodulation, and antioxidant effects 2, 3, 5.
- Hypoalbuminemia is associated with increased mortality and morbidity in elderly people and patients with liver disease 2, 3, 6.
- Albumin levels can be influenced by various factors, including nutrition, inflammation, and liver function 2, 3, 4, 5.