From the Guidelines
Recommended Magnesium Supplementation for Adult Females
For adult women, the recommended dose of magnesium (Mg) oral supplementation to manage hypertension and support hormonal balance is 200-500 mg/day 1.
- This dose range is supported by a strong consensus of 92% in the espen micronutrient guideline, which suggests that patients with chronic oxidative stress or malabsorption may benefit from this dose range 1.
- The supplementation can be provided in the form of magnesium oxide or magnesium citrate, taken in divided doses with meals to enhance absorption.
- The recommended duration of supplementation varies depending on individual response, but often ranges from 3-6 months to achieve optimal blood pressure regulation and hormonal balance.
- In some cases, higher doses of up to 600 mg per day may be necessary, particularly for women with severe magnesium deficiency or those taking medications such as diuretics that can deplete magnesium levels.
- It is essential to note that individual responses may vary, and the dosage should be tailored to each patient's specific needs and health status, as indicated by the guideline's recommendation for patients with chronic oxidative stress or malabsorption 1.
From the FDA Drug Label
DIRECTIONS Antacid Directions:■ take 1 tablet twice a day or as directed by a physician Magnesium Supplement Directions: ■take 1 to 2 tablets daily or as directed by a physician Directions shake well before using drink a full glass (8 ounces) of liquid with each dose may be taken as a single daily dose or in divided doses adults and children 12 years of age and over - 6.5 to 10 fl oz maximum 10 fl oz in 24 hours
The recommended dose of magnesium (Mg) oral supplementation for an adult female is:
- 1 to 2 tablets daily of magnesium oxide (PO) 2
- 6.5 to 10 fl oz of magnesium citrate (PO) per day, which may be taken as a single daily dose or in divided doses 3 Key considerations:
- The dose may vary depending on the specific product and individual needs.
- It is essential to follow the directions as indicated by the physician or the product label.
From the Research
Magnesium Supplementation for Hypertension and Hormonal Balance
The recommended dose of magnesium (Mg) oral supplementation for an adult female to manage hypertension and support hormonal balance is as follows:
- A dose of ≥240 mg/day may safely lower blood pressure in uncontrolled hypertensive patients taking antihypertensive medications 4
- A dose of >600 mg/day is required to safely lower blood pressure in untreated hypertensive patients 4
- A median dose of 368 mg/d for a median duration of 3 months significantly reduced systolic and diastolic blood pressure 5
- Magnesium intake of 500 mg/d to 1000 mg/d may reduce blood pressure as much as 5.6/2.8 mm Hg 6
- Mg supplements may enhance the blood-pressure lowering effect of anti-hypertensive medications in stage 1 hypertensive subjects, with doses as low as 230 mg (10 mmol) per day 7
Key Considerations
- The combination of increased intake of magnesium and potassium coupled with reduced sodium intake is more effective in reducing blood pressure than single mineral intake 6
- Magnesium also increases the effectiveness of all antihypertensive drug classes 6
- Oral magnesium acts as a natural calcium channel blocker, increases nitric oxide, improves endothelial dysfunction, and induces direct and indirect vasodilation 6
- Magnesium supplementation may have a greater effect on blood pressure in patients with high plasma renin activity 8