From the Guidelines
Magnesium L-threonate has therapeutic uses beyond the provided evidence, but based on the given studies, it is not directly mentioned. However, Magnesium is mentioned in the context of various therapeutic uses.
Therapeutic Uses of Magnesium
- Erythromelalgia treatment: Magnesium has been used in the treatment of erythromelalgia, with 8 out of 13 patients experiencing improvement in symptoms when taking high doses of oral magnesium (600 to 6500 mg daily) 1.
- Constipation treatment: Magnesium oxide is suggested for use in adults with chronic idiopathic constipation, with a recommended starting dose that may be increased as needed, while avoiding use in patients with renal insufficiency due to the risk of hypermagnesemia 1.
- Acute ischemic stroke: Magnesium has been tested as a neuroprotective agent in acute ischemic stroke, although preliminary studies showed promise, a subsequent larger clinical trial was negative 1.
It's essential to note that the provided evidence does not directly discuss Magnesium L-threonate, but rather Magnesium in general. Magnesium L-threonate is a specific form of Magnesium that has been studied for its potential cognitive benefits and ability to cross the blood-brain barrier. However, without direct evidence, its therapeutic uses cannot be conclusively stated based on the given studies.
The FDA Drug Labels for magnesium threonate (PO) do not address this question.
From the Research
Therapeutic Uses of Magnesium L-threonate
The therapeutic uses of Magnesium L-threonate include:
- Neuroprotection against hypoxic injuries and cognitive decline 2
- Prevention and reversal of cognitive deficits and synaptic loss in Alzheimer's disease mouse models 3
- Regulation of structural and functional synapse density through modulation of intraneuronal magnesium concentration 4
- Inhibition of cognitive decline in amyloid precursor protein/presenilin 1 transgenic mice by suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein 5
- Enhancement of the memory restorative effect of environmental enrichment in Alzheimer's disease mice 6
Key Findings
Key findings on the therapeutic uses of Magnesium L-threonate include:
- Increased cell viability and memory preservation in zebrafish under hypoxic conditions 2
- Reduced Aβ plaque and prevention of synapse loss and memory decline in Alzheimer's disease mouse models 3
- Elevation of brain magnesium concentration and enhancement of learning and memory in young rats and prevention of memory decline in aging rats and Alzheimer's disease model mice 4
- Suppression of anterior pharynx-defective-1α and -1β expression and inhibition of β-amyloid protein aggregation 5
- Synergistic improvement of recognition and spatial memory with environmental enrichment 6
Mechanisms of Action
The mechanisms of action of Magnesium L-threonate include:
- Modulation of intraneuronal magnesium concentration and regulation of synapse density 4
- Suppression of anterior pharynx-defective-1α and -1β expression and inhibition of β-amyloid protein aggregation 5
- Activation of ERK1/2 and PPARγ signaling pathways 5
- Restoration of the NMDAR signaling pathway and reduction of synaptic loss 6