From the Guidelines
The appropriate dose of cryoprecipitate in infants is 5-10 ml/kg 1.
Key Considerations
- This dose is recommended to increase fibrinogen levels, with an expected increase of approximately 50 mg/dL per 1 U of cryoprecipitate per 10 kg body weight 1.
- The volume of cryoprecipitate to be administered should be prescribed in volume rather than number of units, taking into account the size of the patient 1.
- In cases of bleeding or suspected coagulopathy, this dose may be administered as needed to maintain fibrinogen levels above 100 mg/dL.
Administration Guidelines
- Cryoprecipitate should be given in a dose of 5–10 ml.kg-1 1, which is equivalent to an average dose of 5–10 U (50–200 mL) 1.
- The dose may be adjusted based on laboratory results and clinical response, with subsequent doses administered every 8-12 hours as needed.
- It is essential to consider the size of the child and the clinical context of the bleeding when administering cryoprecipitate, as well as being aware of the potential risks of electrolyte imbalance and hypothermia during rapid administration of blood products 1.