What is the appropriate dose of cryoprecipitate (Cryoprecipitated Antihemophilic Factor) in infants?

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Last updated: February 18, 2025 • View editorial policy

From the Guidelines

The appropriate dose of cryoprecipitate in infants is 5-10 ml/kg 1.

Key Considerations

  • This dose is recommended to increase fibrinogen levels, with an expected increase of approximately 50 mg/dL per 1 U of cryoprecipitate per 10 kg body weight 2.
  • The volume of cryoprecipitate to be administered should be prescribed in volume rather than number of units, taking into account the size of the patient 1.
  • In cases of bleeding or suspected coagulopathy, this dose may be administered as needed to maintain fibrinogen levels above 100 mg/dL.

Administration Guidelines

  • Cryoprecipitate should be given in a dose of 5–10 ml.kg-1 1, which is equivalent to an average dose of 5–10 U (50–200 mL) 2.
  • The dose may be adjusted based on laboratory results and clinical response, with subsequent doses administered every 8-12 hours as needed.
  • It is essential to consider the size of the child and the clinical context of the bleeding when administering cryoprecipitate, as well as being aware of the potential risks of electrolyte imbalance and hypothermia during rapid administration of blood products 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.