From the FDA Drug Label
ADVERSE REACTIONS ... Endocrine: Impotence, changes in libido.
- Low libido is listed as a potential effect under the Endocrine category of adverse reactions.
- The drug label directly supports that amphetamine (Adderall) can cause changes in libido, which may include low libido.
- Based on this information, it can be concluded that Adderall may cause low libido in some individuals 1.
From the Research
Adderall can indeed cause low libido as a side effect, and according to the most recent and highest quality study, individuals with ADHD report more sexual desire, more masturbation frequency, less sexual satisfaction, and more sexual dysfunctions than the general population 2. This medication, which contains amphetamine and dextroamphetamine, is primarily used to treat ADHD and narcolepsy but can affect sexual desire in some users. The impact on libido varies between individuals, with some experiencing significant decreases while others notice minimal or no changes. This side effect occurs because Adderall affects neurotransmitters in the brain, particularly dopamine and norepinephrine, which play roles in sexual function. Additionally, Adderall can cause vasoconstriction (narrowing of blood vessels), which may reduce blood flow to genital areas, potentially affecting arousal. Other factors that might contribute to decreased libido include Adderall's effects on mood, energy levels, and sleep patterns. Some key points to consider:
- A systematic review of the literature on sexuality in subjects with ADHD found that they report more sexual desire, more masturbation frequency, less sexual satisfaction, and more sexual dysfunctions than the general population 2.
- Another study found that psychostimulants, such as dextroamphetamine, can reverse sexual dysfunction secondary to selective serotonin re-uptake inhibitors (SSRIs) 3.
- However, the most recent study on the topic, published in 2021, found a significant association between sexual dysfunction and antidepressant drug therapy, including decreased libido, erectile dysfunction, and ejaculatory dysfunction 4. If you're experiencing this side effect, don't abruptly stop taking the medication, but instead consult your healthcare provider. They might adjust your dosage, recommend taking the medication at different times, suggest a medication holiday when appropriate, or consider alternative treatments for your condition. It's essential to weigh the benefits of Adderall in managing ADHD symptoms against the potential risks of sexual dysfunction and to discuss these concerns with a healthcare provider to determine the best course of action.