From the Guidelines
Recommended Duration to Withhold FOLFOX Before Surgery
FOLFOX should be held for a minimum of 4 weeks prior to surgery to minimize potential surgical complications 1.
- The recommended duration of FOLFOX treatment prior to surgery is 6-8 cycles, with the last cycle administered at least 4 weeks before the planned surgical date 1.
- This interval allows for adequate recovery from the myelosuppressive and neurotoxic effects of oxaliplatin, reducing the risk of postoperative morbidity.
- It is also recommended to discontinue oxaliplatin from FOLFOX after 3 months of therapy, or sooner for unacceptable neurotoxicity, with other drugs in the regimen maintained for the entire 6 months or until tumor progression 1.
- Patients experiencing neurotoxicity on oxaliplatin should not receive subsequent oxaliplatin therapy until and unless they experience near-total resolution of that neurotoxicity 1.