From the Guidelines
Yes, Illus can potentially raise white blood cell (WBC) counts. While the provided study 1 does not directly address the effect of Illus on WBC counts, it discusses the significance of leukocytosis in older adults, indicating a high probability of underlying bacterial infection when the WBC count is elevated. Although this study focuses on older adult residents of long-term care facilities, the principle of leukocytosis being a marker of potential infection or inflammation can be broadly applied. In the context of Illus, which is another term for Ibuprofen Lysine, a non-steroidal anti-inflammatory drug (NSAID), it is plausible that it could cause leukocytosis as a side effect, similar to other NSAIDs. This occurs because NSAIDs can alter the distribution of white blood cells in the body, causing them to demarginate from blood vessel walls and enter the circulation, resulting in a higher measured WBC count. Key points to consider include:
- The mechanism by which NSAIDs like Illus might increase WBC counts involves the demargination of white blood cells from blood vessel walls into the circulation.
- The study 1 highlights the importance of interpreting elevated WBC counts in the context of clinical presentation, as they can indicate underlying infections or other medical conditions.
- It is essential to monitor WBC counts and overall clinical condition when using medications like Illus, especially in vulnerable populations, to promptly identify and address any potential issues.
From the Research
Illness and White Blood Cell Count
- Illness can raise white blood cell (WBC) count, as the body responds to infection or inflammation by increasing the production of WBCs [(2, 3, 4, 5, 6)].
- This increase in WBC count is a common laboratory finding and can be caused by relatively benign conditions, such as infections or inflammatory processes, as well as more serious causes, including primary bone marrow disorders 2.
- Physical stress, emotional stress, and certain medications, such as corticosteroids, lithium, and beta agonists, can also elevate WBC counts 2.
Types of Infections and WBC Count
- Bacterial infections, such as pneumococcal and Escherichia coli infections, can increase total WBC counts 5.
- Viral infections, such as adenoviruses, can also increase WBC counts, although this is less common 5.
- The dynamics of WBC count changes and their resolution are not well established, but studies have identified a universal recovery trajectory defined by exponential WBC decay and delayed linear growth of platelet count [(3, 4)].
Monitoring WBC Count and Left Shift
- Neutrophil left shift and WBC count are routine laboratory tests used to assess neutrophil state and can be used to evaluate the condition of a bacterial infection 6.
- Time-series data of left shift and WBC count can reflect real-time neutrophil consumption during the course of a bacterial infection, allowing for more accurate evaluation of patient condition 6.