From the Research
SSRIs may potentially delay the healing of mouth ulcers in some individuals, as suggested by a case report where a 78-year-old woman developed an oral ulceration after using sertraline hydrochloride 1. The mechanism involves the alteration of serotonin levels, which plays a role in wound healing processes and inflammatory responses. Additionally, some SSRIs may affect blood flow to tissues or immune function, potentially impacting the body's natural healing abilities. Key points to consider include:
- SSRIs have been associated with oral side effects including dry mouth, which can create an environment less conducive to healing 2.
- A population-based case-control study found an association between SSRI use and uncomplicated peptic ulcers, possibly due to an effect on the healing process 3.
- A narrative review highlights the importance of considering the potential adverse effects of SSRIs, including their impact on oral health 4. If you're experiencing persistent mouth ulcers while taking an SSRI, it's essential to maintain good oral hygiene, stay hydrated, and consider using topical treatments like benzocaine gels or antimicrobial mouthwashes to support healing. However, do not discontinue your SSRI medication without consulting your healthcare provider, as the benefits of treating depression or anxiety typically outweigh this potential side effect 5. Your doctor might consider adjusting your dosage or switching to a different medication if mouth ulcers become a significant problem.