What is Patellofemoral (kneecap and femur) syndrome?

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From the Guidelines

Patellofemoral Syndrome

Patellofemoral syndrome is a common condition characterized by anterior knee pain, typically exacerbated by activities such as climbing stairs, squatting, or jumping 1.

Key Characteristics

  • The pain is usually diffuse retropatellar and/or peripatellar and can be persistent, with over 50% of people reporting pain more than 5 years post-diagnosis despite receiving treatment 1.
  • People with patellofemoral pain are six times more likely to be anxious or depressed and have poorer health-related quality of life than their asymptomatic peers 1.

Treatment Approach

Treatment involves a multimodal approach, including:

  • Knee-targeted exercise therapy, with supportive interventions as required 1.
  • Education should underpin all interventions, adjusted to reflect the needs of the person, and may seek to challenge inaccurate beliefs, build confidence, and promote autonomy and reduce fear 1.
  • Prefabricated foot orthoses may be prescribed to those who respond favourably to treatment direction tests and be customized for comfort by modifying density and geometry 1.
  • Movement/running retraining can be considered in those with symptoms reasoned to be associated with assessment findings aligning with the intervention 1.
  • Taping should be considered for people where rehabilitation is hindered by elevated symptom severity and irritability 1.

Important Considerations

  • Goal setting and objective evaluation of physical impairments are crucial in determining the most effective treatment approach 1.
  • Hip-and-knee targeted exercise therapy may be required, with a greater focus on hip exercises in people with poor tolerance to loaded knee flexion 1.
  • Education and supportive interventions should be tailored to the individual's needs and preferences 1.

From the Research

Definition and Causes of Patellofemoral Pain Syndrome

  • Patellofemoral pain syndrome (PFPS) is a common cause of anterior knee pain, affecting adolescents and adults younger than 60 years, with an incidence of 3% to 6% in the United States 2.
  • The cardinal feature of PFPS is pain in or around the anterior knee that intensifies when the knee is flexed during weight-bearing activities, such as squatting, running, jumping, and walking up stairs 2, 3.
  • Potential pain sources include connective or soft tissue irritation, intra-articular cartilage damage, mechanical irritation, nerve-mediated abnormalities, systemic conditions, or psychosocial issues 3.
  • Dynamic valgus of the lower extremity, weak hip muscles, and rearfoot eversion with pes pronatus valgus are key factors in the development of PFPS 4, 5.

Symptoms and Diagnosis

  • Patients with PFPS often report pain during weight-bearing activities that involve significant knee flexion, such as squatting, running, jumping, and walking up stairs 2, 3.
  • The most sensitive physical examination finding is pain with squatting, and examining a patient's gait, posture, and footwear can help identify contributing causes 2.
  • Plain radiographs of the knee are not necessary for the diagnosis of PFPS but can exclude other diagnoses, such as osteoarthritis, patellar fracture, and osteochondritis 2, 3.

Treatment and Management

  • Treatment of PFPS includes rest, a short course of nonsteroidal anti-inflammatory drugs, and physical therapy directed at strengthening the hip flexor, trunk, and knee muscle groups 2, 4, 5.
  • Patellar kinesiotaping may provide additional short-term pain relief, and the use of foot orthoses can also be beneficial in patients with additional foot abnormalities 2, 4, 5, 6.
  • A multimodal non-operative therapy concept with short-term use of NSAIDs, exercise programs, and orthotics is recommended, and patients should be informed that it may take several months for symptoms to resolve 3, 4, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Patellofemoral Pain Syndrome.

American family physician, 2019

Research

Approach to the active patient with chronic anterior knee pain.

The Physician and sportsmedicine, 2012

Research

Patellofemoral pain in athletes.

Open access journal of sports medicine, 2017

Research

Patellofemoral pain syndrome.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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