What is the diagnosis for a patient presenting with 15 days of influenza-like symptoms, initially experiencing nasal congestion, now with chills, sweats, a left-sided rash on the scalp and face, fatigue, and shivering, after a negative at-home COVID-19 (Coronavirus Disease 2019) test, and being treated with Tylenol (Acetaminophen)/ibuprofen?

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Differential Diagnosis

  • Single most likely diagnosis
    • Influenza: The patient's symptoms of flu-like illness, chills, sweats, and fatigue, along with a negative at-home COVID test, make influenza a likely diagnosis. The rash on one side of the scalp and face could be a secondary bacterial infection or a viral exanthem.
  • Other Likely diagnoses
    • Mononucleosis: The patient's prolonged fatigue, fever, and rash could be indicative of infectious mononucleosis, especially if the patient is young.
    • Lyme disease: Although less common, the patient's rash on one side of the face and scalp could be a sign of Lyme disease, particularly if the patient has been exposed to ticks.
    • Viral exanthem: The rash, along with the patient's flu-like symptoms, could be a viral exanthem caused by a variety of viruses, such as enterovirus or adenovirus.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Meningitis: The patient's symptoms of fever, chills, and rash, along with the location of the rash on the scalp and face, could be indicative of meningitis, particularly if the patient has a headache or stiff neck.
    • Rocky Mountain spotted fever: The patient's rash, fever, and headache (if present) could be indicative of Rocky Mountain spotted fever, a tick-borne illness that can be deadly if not treated promptly.
    • Ehrlichiosis/Anaplasmosis: These tick-borne illnesses can present with fever, chills, and rash, and can be severe if not treated promptly.
  • Rare diagnoses
    • Ramsay Hunt syndrome: The patient's rash on one side of the face and scalp could be a sign of Ramsay Hunt syndrome, a rare complication of varicella-zoster virus infection.
    • Erythema migrans: Although the patient's rash is not typically described as a "bull's-eye" rash, it could still be a sign of erythema migrans, an early manifestation of Lyme disease.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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