From the Research
It's generally safe to take rizatriptan and ibuprofen together or at any time interval between them, as they don't have significant interactions. You can take rizatriptan immediately after ibuprofen if needed for migraine relief. Ibuprofen (a non-steroidal anti-inflammatory drug) works by reducing inflammation and pain, while rizatriptan (a triptan) works by narrowing blood vessels in the brain and blocking pain pathways. Some doctors actually recommend taking both medications together for migraine treatment, as they work through different mechanisms. The standard adult dose for rizatriptan is 5-10 mg as needed for migraines (maximum 30 mg per 24 hours), while ibuprofen is typically 400-800 mg every 6-8 hours (maximum 3200 mg daily) 1. However, if you have kidney disease, heart problems, or take certain other medications, you should consult your healthcare provider before combining these medications to ensure safety for your specific situation. Key points to consider when taking rizatriptan and ibuprofen together include:
- Monitoring for increased risk of serotonin syndrome when combining triptans with other serotoninergic drugs 2
- Being aware of potential interactions with other medications, such as CYP3A4 inhibitors 2
- Following the recommended dosages and maximum daily limits for both medications to minimize the risk of adverse effects 1
- Consulting with a healthcare provider before combining these medications if you have any underlying medical conditions or take other medications that may interact with rizatriptan or ibuprofen.