What is the treatment for Cimex lectularius (bed bug) bites?

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Last updated: May 4, 2025View editorial policy

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From the Guidelines

To treat bed bug bites, provide symptomatic treatment if needed, including oral antihistamines and oral analgesics to reduce pain or itching associated with cutaneous reactions, as recommended by the Journal of Allergy and Clinical Immunology 1. When treating bed bug bites, consider the following options:

  • Apply cold compresses to reduce local pain and swelling
  • Use oral antihistamines, such as diphenhydramine, to alleviate itching and pain
  • Utilize oral analgesics to manage pain associated with the bites
  • Avoid using antibiotics unless there is evidence of secondary infection, as the swelling is caused by mediator release and not by infection 1 Some key points to keep in mind:
  • Most insect bites, including bed bug bites, cause mild local reactions that do not require specific treatment
  • Large local reactions may be treated with oral corticosteroids, although definitive proof of efficacy is lacking 1
  • It is essential to address the bed bug infestation in the home to prevent further bites
  • Seek medical attention if signs of an allergic reaction, infection, or other severe symptoms develop.

From the FDA Drug Label

Uses temporarily relieves itching associated with minor skin irritations, inflammation, and rashes due to: ... insect bites

  • Hydrocortisone (TOP) can be used to temporarily relieve itching associated with insect bites, including bed bug bites.
  • The treatment is intended for minor skin irritations and itching.
  • It is recommended to use the product under the advice and supervision of a doctor for other uses 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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