What are the differential diagnoses for a pilonidal (pilonidal sinus) cyst?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 4, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Pilonidal Cyst Differential Diagnosis

When considering a differential diagnosis for a pilonidal cyst, it's essential to evaluate various conditions that could present similarly. The following categories help organize potential diagnoses based on their likelihood and clinical significance.

  • Single Most Likely Diagnosis

    • Pilonidal cyst: This is the most likely diagnosis given the context. A pilonidal cyst is a skin infection that typically occurs near the tailbone, at the top of the cleft of the buttocks. It usually starts as a small, dimple-like pit in the skin that can become infected and filled with pus, leading to severe pain and swelling.
  • Other Likely Diagnoses

    • Furuncle or carbuncle: These are types of skin infections that can occur anywhere on the body, including the area near the tailbone. They are caused by bacteria and can present with similar symptoms to a pilonidal cyst, such as pain, swelling, and pus.
    • Epidermoid cyst: This is a benign cyst that can occur in the skin and may resemble a pilonidal cyst in appearance. However, it is not typically infected and does not usually cause the same level of pain.
    • Hidradenitis suppurativa: This is a chronic skin condition characterized by recurring, painful abscesses and nodules in areas of the body where skin folds occur, such as the armpits, groin, and buttocks.
  • Do Not Miss Diagnoses

    • Anal fistula: Although less common, an anal fistula can present with similar symptoms to a pilonidal cyst, including pain and discharge. It is a tunnel that connects the inside of the anus to the skin around it and can be a sign of a more serious underlying condition.
    • Perianal abscess: This is a collection of pus that can occur near the anus and can be extremely painful. It requires prompt medical attention to prevent complications.
    • Osteomyelitis: This is an infection of the bone and, although rare, can occur in the context of a pilonidal cyst if the infection spreads to the bone. It is a serious condition that requires immediate medical attention.
  • Rare Diagnoses

    • Teratoma: This is a rare type of tumor that can occur in the midline of the body, including near the tailbone. It can present as a cystic mass and may be considered in the differential diagnosis of a pilonidal cyst, although it is much less common.
    • Dermoid cyst: Similar to an epidermoid cyst, a dermoid cyst is a benign cyst that can occur in the skin. However, it can contain various types of tissue, such as hair, skin, and teeth, and is less common than other diagnoses on this list.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.