From the Research
Drotaverine (Drotin) injection can be given in pregnancy, but only when clearly necessary and under close medical supervision, as evidenced by a recent study in 2022 1. The use of drotaverine during pregnancy is a topic of concern due to its potential effects on uterine contractions. However, some studies suggest that it can be used safely in pregnant women.
- A study published in 2022 1 found that oral drotaverine administration had no statistically significant influence on the middle cerebral artery and umbilical artery pulsatility index in women with a risk of preterm birth.
- Another study published in 2014 2 found that drotaverine hydrochloride was effective and safe in shortening the duration of the first stage of labor among nulliparous women with active spontaneous labor.
- A case report published in 2019 3 described a pregnant woman who developed a serum sickness-like reaction after taking drotaverine, but was successfully desensitized to the drug using a rapid 7-step oral desensitization protocol. It is essential to weigh the potential benefits and risks of using drotaverine during pregnancy and to consult a healthcare provider before making any decisions.
- The typical adult dose of drotaverine is 40-80 mg given intramuscularly or intravenously 2-3 times daily.
- Drotaverine works as an antispasmodic by inhibiting phosphodiesterase enzyme, causing smooth muscle relaxation in the gastrointestinal tract, urinary tract, and uterus.
- If you're pregnant and experiencing conditions that might require drotaverine, such as renal colic, biliary colic, or intestinal spasms, consult your healthcare provider immediately to discuss safer alternatives.
- Your doctor will carefully evaluate your specific situation and may consider other medications with better established safety profiles during pregnancy, as seen in a study published in 2007 4.