What is Doxycycline (Doxycycline)?

From the Guidelines

Doxycycline is recommended as a treatment for various conditions, including Lyme disease, at a dosage of 100mg twice daily for 14 days, as supported by the Infectious Diseases Society of America guidelines 1.

Dosage and Administration

The recommended dosage of doxycycline for adults is 100mg twice daily, while for children, the dosage is 4mg/kg per day in 2 divided doses, with a maximum daily dosage of 200-400mg 1.

Indications

Doxycycline is indicated for the treatment of early localized or early disseminated Lyme disease associated with erythema migrans, as well as for the treatment of other conditions such as acne and blepharitis 1.

Contraindications

Doxycycline is contraindicated in patients with allergies to tetracycline antibiotics, as well as in children under 8 years of age and in women who are pregnant or breast-feeding 1.

Adverse Effects

Common adverse effects of doxycycline include gastrointestinal disturbances, photosensitivity, and drug eruptions, while rare but serious adverse effects include pseudotumor cerebri and autoimmune disorders 1.

Special Considerations

In patients with renal impairment, doxycycline can be used safely, but with caution, while in patients with hepatic impairment, the dosage may need to be adjusted 1.

From the Research

Doxyprep (Sodium Picosulfate/Magnesium Citrate) Efficacy and Safety

• Sodium picosulfate/magnesium citrate is a dual-action, low-volume bowel cleanser used for colonoscopy preparation 2, 3, 4, 5, 6
• Studies have shown that sodium picosulfate/magnesium citrate is noninferior to polyethylene glycol (PEG) solutions in terms of efficacy and safety 2, 3, 5, 6
• The preparation has been found to be effective in achieving adequate bowel cleansing, with success rates ranging from 75.8% to 84.2% 2, 3, 5, 6

Patient Tolerability and Acceptability

• Sodium picosulfate/magnesium citrate has been found to be better tolerated and more acceptable to patients compared to PEG solutions, with lower incidence of symptoms such as abdominal fullness and pain 5, 6
• Patient-reported tolerability and satisfaction were significantly higher for sodium picosulfate/magnesium citrate compared to PEG solutions 5, 6

Comparison with Other Bowel Preparations

• Sodium picosulfate/magnesium citrate has been compared to other bowel preparations, including PEG solutions, sodium phosphate enema preparations, and oral bisacodyl, and has been found to be at least as effective and well-tolerated 2, 3, 4, 5, 6
• The preparation has been found to be superior to 2L PEG-3350 and bisacodyl tablets in overall colon cleansing and in cleansing of specific segments of the colon 6

Safety and Adverse Events

• Sodium picosulfate/magnesium citrate has been found to be safe and well-tolerated, with commonly reported adverse events including nausea, vomiting, headache, and chills 3, 5, 6
• The incidence of adverse events was similar to or lower than that of PEG solutions and other bowel preparations 3, 5, 6