What is silent inflammation, also known as chronic low-grade inflammation (CLGI)?

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Last updated: May 5, 2025View editorial policy

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From the Research

Silent inflammation, also known as chronic low-grade inflammation, is a persistent inflammatory response in the body that occurs without obvious symptoms and is strongly associated with the development of several chronic diseases, as discussed in a recent review published in 2025 1. This type of inflammation can persist for years, gradually damaging tissues and potentially contributing to various chronic diseases including heart disease, diabetes, cancer, Alzheimer's disease, and autoimmune disorders. Some key factors that trigger silent inflammation include:

  • Poor diet, especially one high in processed foods, sugar, and unhealthy fats
  • Chronic stress
  • Insufficient sleep
  • Environmental toxins
  • Obesity
  • Lack of physical activity The body's immune system remains in a state of low-level activation, continuously releasing inflammatory chemicals that can damage blood vessels, organs, and tissues over time. Managing silent inflammation typically involves adopting an anti-inflammatory diet rich in:
  • Fruits
  • Vegetables
  • Omega-3 fatty acids, as supported by a study published in 2019 2
  • Antioxidants Regular exercise, stress reduction techniques, adequate sleep, and maintaining a healthy weight are also essential lifestyle modifications that help reduce inflammatory processes in the body and may prevent the development of chronic diseases associated with long-term inflammation. Additionally, the Mediterranean diet, which is rich in omega-3 fatty acids and polyphenols, has been shown to have vasculo-protective effects and may help reduce the risk of cardiovascular disease, as discussed in a study published in 2019 3. Overall, addressing silent inflammation is crucial to preventing and managing chronic diseases, and a comprehensive approach that incorporates lifestyle modifications and a balanced diet is essential for reducing morbidity, mortality, and improving quality of life.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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