What is the cause of my persistent nasal congestion?

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Last updated: May 5, 2025 • View editorial policy

Differential Diagnosis for a Stuffy Nose

  • Single most likely diagnosis + Allergic rhinitis: This is the most common cause of a stuffy nose, often triggered by allergens such as pollen, dust mites, or pet dander, leading to chronic inflammation and nasal congestion.
  • Other Likely diagnoses + Vasomotor rhinitis: A non-allergic condition characterized by excessive nasal blood flow, leading to persistent nasal congestion, often triggered by environmental factors such as temperature or humidity changes. + Chronic sinusitis: A condition where the sinuses become inflamed or infected, causing nasal congestion, facial pain, and discharge. + Deviated septum: A physical obstruction in the nasal passage that can cause uneven airflow, leading to nasal congestion on one side. + Nasal polyps: Growths in the nasal passage that can cause obstruction and congestion.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.) + Nasopharyngeal carcinoma: A rare type of cancer that can cause nasal congestion, bleeding, and other symptoms. + Granulomatosis with polyangiitis (GPA): A rare autoimmune disorder that can cause nasal congestion, sinusitis, and other systemic symptoms. + Sarcoidosis: A condition that can cause granulomas to form in the nose and sinuses, leading to congestion and other symptoms.
  • Rare diagnoses + Primary ciliary dyskinesia: A rare genetic disorder that affects the movement of cilia in the nose and sinuses, leading to chronic congestion and infections. + Cystic fibrosis: A genetic disorder that can cause thick, sticky mucus to build up in the nose and sinuses, leading to congestion and infections. + Atrophic rhinitis: A rare condition characterized by atrophy of the nasal mucosa, leading to a wide nasal cavity and symptoms such as congestion and crusting.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.