How to order magic mouthwash (mouthwash containing ingredients such as lidocaine, diphenhydramine, and Maalox (aluminum hydroxide, magnesium hydroxide, and simethicone))?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 5, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

To order magic mouthwash, contact your healthcare provider who can write a prescription for this compounded medication, as the exact formulation varies based on your specific condition and provider preference, and is supported by guidelines such as those from the National Comprehensive Cancer Network 1. When ordering magic mouthwash, it is essential to follow the healthcare provider's instructions, as the composition of the mouthwash can vary significantly, including ingredients such as antibiotics, antihistamines, antifungals, corticosteroids, and antacids 1.

  • The effectiveness of these ingredients for preventing or treating mucositis and the evidence supporting their use varies, with some studies suggesting that bland mouth rinses using ingredients such as sodium bicarbonate are often recommended 1.
  • Local anesthetics, such as lidocaine, may be used to treat mucositis either as a component of a mouth rinse or separately, in a liquid or gel formulation, and the NSAID benzydamine also has some data supporting its use in an oral rinse for the prevention and treatment of mucositis 1. Once prescribed, take the prescription to a pharmacy that offers compounding services, as not all pharmacies can prepare this medication, and some larger hospital pharmacies or specialized compounding pharmacies are more likely to provide this service.
  • When using magic mouthwash, you'll typically swish 1-2 teaspoons in your mouth for 1-2 minutes before spitting it out or swallowing (depending on your provider's instructions), usually 4-6 times daily, to help manage mouth sores, oral mucositis, or throat pain from conditions like chemotherapy side effects, radiation therapy, or oral infections 1. It is crucial to follow the healthcare provider's instructions and guidelines, such as those from the National Comprehensive Cancer Network, to ensure the safe and effective use of magic mouthwash 1.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Magic Mouthwash Ordering Information

  • There is no direct information on how to order magic mouthwash in the provided studies 2, 3, 4, 5, 6.
  • However, the ingredients and formulations of magic mouthwash are discussed in some studies, which may be useful for healthcare professionals or patients looking to obtain a prescription or prepare the mouthwash themselves 2, 3.
  • The study by 2 discusses the beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations, which may be relevant for pharmacists or healthcare professionals preparing the mouthwash.
  • Another study by 3 describes the development and stability of an innovative formulation of nystatin and lidocaine pastilles for the treatment of oral mucositis, which may be an alternative to traditional magic mouthwash formulations.

Key Ingredients and Formulations

  • The magic mouthwash formulations discussed in the studies typically contain ingredients such as lidocaine, diphenhydramine, and aluminum hydroxide-magnesium hydroxide-simethicone 2.
  • The study by 3 describes a pastille formulation containing nystatin and lidocaine, which may be an alternative to traditional magic mouthwash formulations.
  • Topical lidocaine is also discussed as a treatment option for chronic pain in several studies 4, 6, which may be relevant for patients looking to use magic mouthwash for pain management.

Safety and Efficacy

  • The safety and efficacy of magic mouthwash ingredients are discussed in several studies, including the potential for allergic contact dermatitis to topical medicaments such as lidocaine 5.
  • The study by 6 discusses the efficacy and safety of topical lidocaine for chronic pain treatment, which may be relevant for patients looking to use magic mouthwash for pain management.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2017

Research

Nystatin and lidocaine pastilles for the local treatment of oral mucositis.

Pharmaceutical development and technology, 2017

Research

Comprehensive Review of Topical Analgesics for Chronic Pain.

Current pain and headache reports, 2021

Research

Topical Lidocaine for Chronic Pain Treatment.

Drug design, development and therapy, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.