What is the onset of action of Voriconazole (Vfend) in treating Aspergillus infections?

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Voriconazole genellikle Aspergillus enfeksiyonlarına karşı 24-48 saat içinde etki gösterir, ancak görünür klinik iyileşme birkaç gün ila bir hafta sürebilir. Bu süre zarfında, hastaların tedaviye yanıt verip vermediğini yakından takip etmek önemlidir. Voriconazole, fungal hücre zarfının ergosterol sentezini bozan fungal sitokrom P450-bağımlı 14α-lanosterol demetilasyonunu inhibe ederek çalışır 1. Tedavi süresince, hastaların yan etkileri hakkında bilgilendirilmesi önemlidir, bunlar arasında görme bozuklukları, cilt reaksiyonları ve karaciğer fonksiyon anormallikleri bulunur 2. Ayrıca, voriconazoleün birçok ilaç ile etkileşime girebileceği dikkate alınmalıdır 3. Voriconazole tedavisinin etkinliği ve güvenliği konusunda yapılan çalışmalar, bu ilacın invazif aspergillosis tedavisinde etkili ve güvenli bir seçenek olduğunu göstermiştir 4, 5. Ancak, her hasta için en uygun tedavi planını belirlemek amacıyla, hastanın genel sağlık durumu, diğer ilaçları ve olası ilaç etkileşimleri dikkate alınmalıdır. Bu nedenle, voriconazole tedavisine başlamadan önce, hastanın ayrıntılı bir şekilde değerlendirilmesi ve tedavi planının bir sağlık uzmanı tarafından belirlenmesi önemlidir.

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