Differential Diagnosis for Missed Period in a 30-year-old Female
Single Most Likely Diagnosis
- Pregnancy: This is the most common cause of a missed period in a woman of childbearing age. A pregnancy test should be the first step in evaluation.
Other Likely Diagnoses
- Polycystic Ovary Syndrome (PCOS): A hormonal disorder that can cause irregular periods, PCOS is a common condition in women of reproductive age.
- Stress or Weight Changes: Significant stress or changes in weight can disrupt the menstrual cycle, leading to missed periods.
- Hormonal Imbalance: Thyroid disorders or other hormonal imbalances can affect the menstrual cycle.
- Birth Control or Hormonal Medications: Certain medications, especially hormonal contraceptives, can cause changes in menstrual patterns.
Do Not Miss Diagnoses
- Ectopic Pregnancy: Although less common, an ectopic pregnancy is a life-threatening condition that must be ruled out in any woman of childbearing age presenting with a missed period and abdominal pain.
- Ovarian Torsion: A rare but emergency condition where the ovary twists, cutting off its blood supply. It requires immediate medical attention.
- Pituitary Tumor: Although rare, a tumor in the pituitary gland can cause hormonal imbalances leading to missed periods.
Rare Diagnoses
- Premature Ovarian Failure (POF): A condition where the ovaries stop functioning and menstruation stops before the age of 40.
- Asherman's Syndrome: A rare condition where scar tissue forms in the uterus, often after uterine surgery, which can lead to missed periods.
- Sheehan Syndrome: A rare condition caused by necrosis of the pituitary gland, often after childbirth, leading to hormonal deficiencies and missed periods.