From the Research
Asciminib (Scemblix) typically does not need to be held for a colonoscopy, as it is a tyrosine kinase inhibitor used for chronic myeloid leukemia that doesn't significantly affect coagulation, according to the most recent and highest quality studies available 1, 2. When considering the management of medications before a colonoscopy, it's essential to prioritize those that may increase the risk of bleeding, such as anticoagulants or certain NSAIDs.
- The main medications that need to be temporarily discontinued before colonoscopy are blood thinners, certain diabetes medications, and iron supplements.
- Asciminib, being a tyrosine kinase inhibitor, does not fall into the category of medications that significantly affect coagulation, and thus, it can be continued as prescribed before and after the colonoscopy procedure.
- However, it is crucial to inform your gastroenterologist about all medications you're taking, including asciminib, during your pre-procedure consultation, as they may have specific recommendations based on your complete medical history.
- Studies have shown that the risk of bleeding after colonoscopy is relatively low, with a pooled rate of 1.64/1000, and that certain factors such as older age, male sex, having a polypectomy, and having the colonoscopy performed by a low-volume endoscopist are associated with increased odds of bleeding or perforation 3.
- More recent studies have explored the use of tranexamic acid to prevent bleeding after endoscopic resection of large colorectal polyps, showing promising results in reducing blood loss and the need for transfusion 4, 1.