From the Guidelines
Clindamycin gel can be used during pregnancy when necessary, as moderate evidence supports its safety, according to the most recent guidelines 1.
Key Considerations
- The use of clindamycin in pregnancy is considered safe, with minimal risks of congenital anomalies or preterm delivery, as stated in the 2025 North American clinical practice guidelines for the medical management of hidradenitis suppurativa in special patient populations 1.
- Although older studies raised concerns about the use of clindamycin during pregnancy, such as increased risk of preterm delivery 1 and neonatal sepsis 1, these findings are not supported by more recent and higher-quality evidence.
- It is essential to consult with a healthcare provider before using clindamycin gel during pregnancy to weigh the benefits against any potential risks based on the individual's pregnancy stage and medical history.
Important Details
- Clindamycin gel is typically applied topically, resulting in minimal absorption into the bloodstream and reducing potential risks to the developing baby.
- Common formulations include 1% or 2% strengths, applied as directed by a healthcare provider, typically once or twice daily to affected areas.
- Potential side effects may include skin irritation, dryness, or redness at the application site, which should be reported to a doctor if severe or persistent.
Recommendation
Based on the most recent and highest-quality evidence, clindamycin gel can be used during pregnancy when necessary, and its use should be determined on a case-by-case basis, considering the individual's specific situation and medical history 1.
From the FDA Drug Label
Pregnancy: Teratogenic effects In clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters has not been associated with an increased frequency of congenital abnormalities. There are no adequate studies in pregnant women during the first trimester of pregnancy Clindamycin should be used during the first trimester of pregnancy only if clearly needed.
- Clindamycin gel can be used in pregnancy, but with caution.
- It is recommended to use clindamycin during the first trimester of pregnancy only if clearly needed.
- There are no adequate studies in pregnant women during the first trimester of pregnancy, but systemic administration of clindamycin during the second and third trimesters has not been associated with an increased frequency of congenital abnormalities 2.
From the Research
Clindamycin Gel Use in Pregnancy
- Clindamycin gel can be used to treat acne in pregnant women, as it is considered a safe topical medication for this purpose 3, 4.
- Topical antibiotics, including clindamycin, are recommended as first-line treatment for acne vulgaris in pregnant and lactating women 3.
- Clindamycin is effective in reducing inflammatory acne lesions and has been shown to be safe for use during pregnancy 4.
- The use of clindamycin gel in pregnancy is supported by studies that have evaluated the safety and efficacy of topical antibiotics for acne treatment 5, 6.
- While there are no direct studies on the use of clindamycin gel in pregnancy, the available evidence suggests that it can be used as a safe and effective treatment option for acne in pregnant women 3, 4.