From the Guidelines
A comprehensive workup should include laboratory tests such as a Complete Blood Count (CBC) with differential, blood chemistry tests, including liver and kidney function tests, and measurement of electrolytes, hepatic transaminase enzymes, and total bilirubin 1.
Initial Laboratory Tests
- Complete Blood Count (CBC) with differential to assess for anemia, leukocytosis, or thrombocytopenia 1
- Blood chemistry tests, including liver and kidney function tests, to evaluate for any underlying organ dysfunction 1
- Measurement of electrolytes, hepatic transaminase enzymes, and total bilirubin to assess for any electrolyte imbalances or liver dysfunction 1
Additional Tests
- At least 2 sets of blood cultures to rule out bacteremia or sepsis, with a set collected simultaneously from each lumen of an existing central venous catheter (CVC), if present, and from a peripheral vein site 1
- Culture specimens from other sites of suspected infection should be obtained as clinically indicated 1
- Chest radiograph is indicated for patients with respiratory signs or symptoms 1
- Urinalysis to assess for any urinary tract infections or kidney dysfunction 1
- Erythrocyte Sedimentation Rate (ESR) or C-Reactive Protein (CRP) to assess for inflammation 1 It is essential to consult a healthcare professional for personalized guidance and interpretation of test results.
From the Research
Laboratory Tests for Comprehensive Workup
The following laboratory tests are indicated for a comprehensive workup:
- Complete blood count with differential 2
- Hepatic function testing 2
- Renal function testing 2
- Thyroid function testing 2
- Diabetes screening 2
- Magnetic resonance imaging-proton density fat fraction (MRI-PDFF) for diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) 3
- Magnetic resonance elastography (MRE) for diagnosis of significant hepatic fibrosis 3
- Serum ferritin testing to identify hyperferritinaemia, a potential biomarker for MASLD and significant fibrosis 3
Additional Testing
Further testing may be guided by history and physical examination findings, such as:
- Blood eosinophils to serve as a biomarker of T helper cell type 2 polarization and response to immunomodulator therapies in individuals with chronic pruritus of unknown origin 2
- Biopsy to identify distinct features and guide treatment of multifocal vascular lesions 4
- Radiological imaging to identify distinct features and guide treatment of multifocal vascular lesions 4