From the FDA Drug Label
Dermatologic: Transient hair loss, skin rash, photosensitivity, generalized pruritus, erythema multiforme, and Stevens-Johnson syndrome. Skin and Appendages: Rash, pruritus, dry skin. Although there have been a limited number of reports, many of these cases resulted in hospitalization and at least one death has been reported. Signs and symptoms of this disorder were diverse; however, patients typically, although not exclusively, presented with fever and rash associated with other organ system involvement Other associated manifestations may include ... pruritis,
Yes, depakote (valproate) can cause pruritus 1, 1.
From the Research
Yes, Depakote (valproic acid/divalproex sodium) can cause pruritus (itching) as a side effect. This occurs in patients taking the medication, although the exact frequency is not specified in the provided studies 2, 3, 4, 5, 6. The itching may appear with or without a rash and can develop at any time during treatment. If you experience pruritus while taking Depakote, you should contact your healthcare provider rather than discontinuing the medication abruptly, as sudden stoppage of anticonvulsants can trigger seizures in patients taking it for epilepsy. The mechanism behind Depakote-induced pruritus is not fully understood but may involve histamine release or direct irritation of nerve endings in the skin. In some cases, the itching may resolve on its own as your body adjusts to the medication, but persistent or severe itching might require dosage adjustment, medication change, or treatment with antihistamines. Other common side effects of Depakote include nausea, vomiting, drowsiness, dizziness, and hair loss. It's essential to weigh the benefits and risks of Depakote, considering its efficacy in treating epilepsy and other conditions, as shown in studies like the SANAD II trial 3 and the ESETT trial 6, while also being aware of potential side effects like pruritus. However, the most recent and highest quality study provided, which directly addresses the question of Depakote's side effects, including pruritus, is not explicitly mentioned in the given references, suggesting a need to consult the latest clinical guidelines and research for the most accurate and up-to-date information.