From the Guidelines
The concentration of testosterone in a 2.5% testosterone cream is 2.5%, which means that for every 100 grams of cream, there are 2.5 grams of testosterone 1.
Calculation of Testosterone Concentration
- To calculate the amount of testosterone in a given amount of cream, multiply the weight of the cream by 0.025 (which is 2.5%).
- For example, in a 100 gram cream, the amount of testosterone would be 100 grams * 0.025 = 2.5 grams.
- This concentration is used in topical applications, such as for male genital lichen sclerosus 1.
Daily Dose Calculation
- If a daily dose of 4 grams of cream is applied, then the amount of testosterone in this dose would be 4 grams * 0.025 = 0.1 grams or 100mg.
- This daily dose of 100mg of testosterone is applied topically, as part of the treatment regimen 1.
From the Research
Concentration of Testosterone in 2.5% Testosterone Cream
- The concentration of testosterone in a 2.5% testosterone cream is 2.5% by weight, which means that 2.5 grams of testosterone are present in every 100 grams of cream 2, 3, 4, 5, 6.
- However, the exact concentration of testosterone in a 2.5% testosterone cream in terms of nanograms per deciliter (ng/dL) or nanomoles per liter (nmol/L) is not directly stated in the provided studies.
- The studies provide information on the pharmacokinetics and efficacy of different testosterone formulations, including creams and gels, but do not specifically address the concentration of testosterone in a 2.5% cream.
- It is worth noting that the concentration of testosterone in a cream or gel can vary depending on the specific formulation and manufacturer, and may not always be directly equivalent to the stated percentage concentration 3, 4, 6.
Pharmacokinetics of Testosterone Cream
- The pharmacokinetics of testosterone cream have been studied in several trials, including a study on the scrotal skin route, which found that testosterone administration onto the scrotal skin produced a swift and dose-dependent increase in serum testosterone levels 4.
- Another study found that therapeutic levels of testosterone were reached within two hours after application of testosterone cream via scrotal delivery, with consistent concentrations remaining beyond six hours 5.
- These studies suggest that testosterone cream can be an effective method for delivering testosterone, but the specific concentration of testosterone in a 2.5% cream is not addressed.
Efficacy and Safety of Testosterone Replacement Therapy
- The provided studies demonstrate the efficacy and safety of testosterone replacement therapy using different formulations, including creams and gels 2, 3, 6.
- These studies found that testosterone replacement therapy can effectively increase serum testosterone levels and improve symptoms in hypogonadal men, with a good safety profile.
- However, the specific concentration of testosterone in a 2.5% cream is not addressed in these studies.