From the Research
Pyridostigmine for pediatric patients is typically dosed at 0.25-2.0 mg/kg/day, as this range has been shown to be effective and safe in children with gastrointestinal motility disorders 1. The dosing of pyridostigmine in pediatric patients can vary depending on the specific condition being treated and the individual patient's response to the medication.
- The medication is an acetylcholinesterase inhibitor that prevents the breakdown of acetylcholine at neuromuscular junctions, making it effective for treating various conditions, including gastrointestinal motility disorders.
- Common side effects of pyridostigmine include gastrointestinal symptoms like nausea, vomiting, and diarrhea, as well as cramping abdominal pain in some cases 1.
- Monitoring for adverse effects is essential, and the medication should be administered with food to minimize gastrointestinal side effects.
- Dosing should be individualized based on clinical response and adjusted gradually to achieve the desired effect while minimizing side effects.
- The effective dosing range of 0.25-2.0 mg/kg/day is based on a case series of children with gastrointestinal motility disorders, including chronic intestinal pseudo-obstruction, gastroparesis, and chronic constipation 1.