What are the differential diagnoses for Attention Deficit Hyperactivity Disorder (ADHD)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnoses for ADHD

When considering a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), it's crucial to rule out other conditions that may present with similar symptoms. The differential diagnoses can be categorized as follows:

  • Single Most Likely Diagnosis
    • Disruptive Mood Dysregulation Disorder (DMDD): This condition often presents with symptoms of irritability and mood dysregulation, which can be mistaken for the impulsivity and hyperactivity seen in ADHD. A thorough evaluation is necessary to distinguish between the two.
  • Other Likely Diagnoses
    • Anxiety Disorders: Anxiety can manifest as restlessness, difficulty concentrating, and impulsivity, mimicking ADHD symptoms. A comprehensive psychiatric evaluation can help differentiate between the two.
    • Depressive Disorders: Depression, particularly in children and adolescents, can present with symptoms of inattention and irritability, which may be confused with ADHD.
    • Sleep Disorders: Sleep apnea, insomnia, and other sleep disorders can lead to symptoms of inattention, fatigue, and decreased productivity, similar to those seen in ADHD.
    • Learning Disabilities: Conditions such as dyslexia, dysgraphia, and dyscalculia can cause difficulties with attention and academic performance, which may be misattributed to ADHD.
  • Do Not Miss Diagnoses
    • Thyroid Disorders: Both hyperthyroidism and hypothyroidism can cause symptoms of anxiety, irritability, and cognitive impairment, which may be mistaken for ADHD. It is essential to rule out these conditions due to their potential for serious health consequences if left untreated.
    • Substance Abuse: Substance use can lead to symptoms of inattention, impulsivity, and hyperactivity, making it crucial to assess for substance abuse in individuals presenting with ADHD-like symptoms.
    • Traumatic Brain Injury: A history of traumatic brain injury can result in symptoms similar to those of ADHD, including attention deficits and impulsivity. Failing to recognize and address the underlying cause could lead to inappropriate treatment.
  • Rare Diagnoses
    • Pheochromocytoma: This rare tumor of the adrenal gland can cause symptoms of anxiety, irritability, and hyperactivity due to excessive catecholamine production.
    • Heavy Metal Poisoning: Exposure to heavy metals like lead or mercury can lead to neurological symptoms, including attention deficits and hyperactivity.
    • Neurodegenerative Disorders: Certain neurodegenerative conditions, such as Huntington's disease, can present with symptoms of inattention, impulsivity, and hyperactivity, although these are typically accompanied by other distinctive features.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.