What is the diagnosis for a 23-year-old male (YOM) who experienced a fall while playing soccer, presenting with a warm, swollen, and erythematous left knee?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for a 23-Year-Old Male with Left Knee Injury

Single Most Likely Diagnosis

  • Ligament Sprain (e.g., ACL, MCL): The patient's symptoms of a warm, swollen, and erythematous knee after a fall during soccer are consistent with a ligament sprain, which is a common injury in sports involving sudden stops and changes in direction.

Other Likely Diagnoses

  • Meniscal Tear: A meniscal tear could also present with similar symptoms, especially if the patient experienced a twisting injury during the fall.
  • Fracture (e.g., Tibial Plateau): Although less likely than a sprain, a fracture could occur if the patient landed directly on the knee or experienced a severe twisting force.
  • Contusion or Hemarthrosis: A direct blow to the knee could result in a contusion or hemarthrosis, leading to swelling and erythema.

Do Not Miss Diagnoses

  • Septic Arthritis: Although unlikely, septic arthritis is a potentially devastating condition that requires prompt diagnosis and treatment. A warm, swollen, and erythematous joint could be indicative of a septic joint, especially if the patient has a fever or other systemic symptoms.
  • Osteonecrosis: If the patient has a history of steroid use or other risk factors, osteonecrosis could be a consideration, although it is less likely in this acute presentation.
  • Vascular Injury: A vascular injury, such as a popliteal artery injury, could occur if the patient experienced a severe knee injury, and is a critical diagnosis not to miss.

Rare Diagnoses

  • Osteochondritis Dissecans: This condition involves a fragment of cartilage and bone becoming detached from the surrounding bone, and could present with knee pain and swelling, although it is less common in adults.
  • Pigmented Villonodular Synovitis (PVNS): A rare condition characterized by synovial proliferation and pigmentation, PVNS could cause chronic knee pain and swelling, although it is unlikely in this acute presentation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.