Are there high-quality studies comparing intravenous (IV) access to intraosseous (IO) access outside of cardiac arrest?

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Last updated: February 7, 2025View editorial policy

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From the Research

Comparison of IV and IO Access

  • The available studies primarily focus on the comparison of intravenous (IV) and intraosseous (IO) access in the context of cardiac arrest, with limited information on their use outside of this specific scenario 1, 2, 3, 4, 5.
  • Studies have shown mixed results regarding the effectiveness of IV and IO access in cardiac arrest patients, with some indicating higher return of spontaneous circulation (ROSC) rates with IV access 4, while others found no significant difference in sustained ROSC between the two methods 3.
  • A randomized controlled trial found that tibial intraosseous access had the highest first-attempt success rate and the most rapid time to vascular access compared to humeral intraosseous and peripheral intravenous access during out-of-hospital cardiac arrest 5.

Limitations and Gaps in Research

  • The current evidence is largely limited to the context of cardiac arrest, with a lack of high-quality studies comparing IV and IO access in other scenarios 1, 2, 3, 4, 5.
  • Many of the existing studies have methodological limitations, such as small sample sizes, retrospective designs, and significant heterogeneity across studies 1, 4.
  • Further research is needed to fully understand the comparative effectiveness of IV and IO access in various clinical settings and to inform evidence-based guidelines for vascular access 2, 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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