Can Unisom (doxylamine) cause hallucinations?

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Last updated: May 6, 2025View editorial policy

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From the Guidelines

Unisom can potentially cause hallucinations, particularly in vulnerable populations such as the elderly or those with certain medical conditions. When considering the potential for hallucinations as a side effect of Unisom, it's essential to weigh the risks and benefits, especially in populations that may be more susceptible to adverse effects. The active ingredients in Unisom, doxylamine succinate or diphenhydramine hydrochloride, are antihistamines that can cross the blood-brain barrier and affect neurotransmitters, potentially leading to hallucinations 1.

Key Considerations

  • Hallucinations are more likely to occur in higher than recommended doses or when combined with other medications or substances.
  • Elderly individuals, those with dementia, liver or kidney disease, or people taking other medications that affect the central nervous system are at higher risk for experiencing hallucinations as a side effect.
  • If hallucinations occur while taking Unisom, the medication should be discontinued immediately, and medical attention sought.

Recommendations for Use

  • Always use Unisom only as directed on the packaging.
  • Consult with a healthcare provider before use if you have any underlying health conditions or take other medications. Given the potential risks, it is crucial to approach the use of Unisom with caution, especially in vulnerable populations, and to prioritize alternative treatments or management strategies when possible, as suggested by recent guidelines on managing sleep disorders 1.

From the Research

Unisom and Hallucinations

  • There are no research papers provided that directly address the question of whether Unisom causes hallucinations.
  • The studies available focus on various topics such as cognitive behavioral therapy for insomnia 2, pharmacological interventions for Disruptive Mood Dysregulation Disorder (DMDD) 3, the effects of medicinal cannabis on mental health 4, cognitive-behavioral therapy for management of mental health and stress-related disorders 5, and basic strategies of cognitive behavioral therapy 6.
  • None of these studies mention Unisom or its potential to cause hallucinations, suggesting that there may not be sufficient research available to provide a definitive answer to this question.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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