What is the diagnosis for a 44-year-old female with leukocytosis (elevated White Blood Cell (WBC) count), anemia (low Red Blood Cell (RBC) count, low Hemoglobin (Hb), and low Hematocrit (Hct)), and thrombocytopenia is not present (normal Platelets count)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis

The patient's laboratory results show a consistent pattern of low hemoglobin, hematocrit, and RBC count, with relatively normal WBC and platelet counts. Based on these findings, the following differential diagnoses are considered:

  • Single most likely diagnosis
    • Iron Deficiency Anemia: The patient's low hemoglobin, hematocrit, and RBC count, along with a low MCHC, suggest iron deficiency anemia. The RDW is also slightly elevated, which is consistent with this diagnosis.
  • Other Likely diagnoses
    • Chronic Disease Anemia: The patient's low hemoglobin and hematocrit, along with a normal WBC and platelet count, could also suggest chronic disease anemia. However, the MCHC is low, which is more consistent with iron deficiency anemia.
    • Anemia of Chronic Kidney Disease: The patient's low hemoglobin and hematocrit could also be due to anemia of chronic kidney disease. However, there is no other evidence of kidney disease in the laboratory results.
  • Do Not Miss
    • Acute Blood Loss: Although the patient's laboratory results do not suggest acute blood loss, it is a potentially life-threatening condition that must be considered. A thorough history and physical examination are necessary to rule out this possibility.
    • Malignancy: Although the patient's laboratory results do not suggest malignancy, it is a potentially life-threatening condition that must be considered. A thorough history, physical examination, and additional testing are necessary to rule out this possibility.
  • Rare diagnoses
    • Thalassemia: The patient's low MCHC and MCV could suggest thalassemia. However, the patient's age and lack of other symptoms make this diagnosis less likely.
    • Sideroblastic Anemia: The patient's low MCHC and MCV could also suggest sideroblastic anemia. However, this diagnosis is rare and would require additional testing to confirm.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.