What causes Osteochondritis Dissecans (OCD) lesions?

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Last updated: May 6, 2025View editorial policy

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From the Research

OCD lesions happen when a segment of bone and its overlying articular cartilage partially or completely separates from the surrounding healthy bone, typically due to repetitive microtrauma, compromised blood supply to the subchondral bone, or genetic factors, as noted in the most recent study 1. The condition develops most commonly in adolescents and young adults, especially those involved in high-impact sports or activities that place repetitive stress on joints. Some key points to consider include:

  • The disruption in blood flow leads to avascular necrosis of the bone segment, which weakens the connection between the affected fragment and the underlying bone, as discussed in 2.
  • As the condition progresses, the fragment may become unstable and eventually detach, creating a loose body within the joint that can cause mechanical symptoms such as catching or locking, as mentioned in 3.
  • Early diagnosis and treatment are essential to prevent progression to osteoarthritis and long-term joint dysfunction, with treatment options ranging from conservative management to surgical procedures such as osteochondral fixation, abrasion chondroplasty, or cartilage restoration, as outlined in 4 and 1. The most recent and highest quality study 1 highlights the importance of considering the stability of the OCD lesion, as well as the patient's age and skeletal maturity, when determining the proper course of treatment. Some of the key factors to consider when evaluating OCD lesions include:
  • The location and size of the lesion, as discussed in 5.
  • The presence of any mechanical symptoms, such as catching or locking, as mentioned in 3.
  • The patient's overall health and activity level, as noted in 2. By considering these factors and using the most recent and highest quality evidence, healthcare providers can develop effective treatment plans to manage OCD lesions and prevent long-term joint dysfunction.

References

Research

Osteochondritis Dissecans Lesions of the Knee: Evidence-Based Treatment.

The Journal of the American Academy of Orthopaedic Surgeons, 2024

Research

Management of Symptomatic Osteochondritis Dissecans of the Knee.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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