What is the differential diagnosis, workup, and plan for a 67-year-old male who experienced a loss of consciousness (LOC) and fall while brushing his teeth, with subsequent amnesia?

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Last updated: February 18, 2025 • View editorial policy

Differential Diagnosis for 67-year-old Male with Fall and Loss of Consciousness

Single Most Likely Diagnosis

  • Cardiac Arrhythmia: The sudden loss of consciousness while performing a routine activity like brushing teeth suggests a possible cardiac cause, such as an arrhythmia, which could lead to a transient loss of consciousness.

Other Likely Diagnoses

  • Orthostatic Hypotension: A sudden drop in blood pressure upon standing could cause a fall and brief loss of consciousness, especially in older adults or those with autonomic dysfunction.
  • Seizure: A seizure could cause a loss of consciousness and a fall, with the patient having no recollection of the event.
  • Vasovagal Syncope: A common cause of fainting spells, often triggered by stress, pain, or prolonged standing, which could be precipitated by the physical act of brushing teeth or other factors.

Do Not Miss Diagnoses

  • Stroke or Transient Ischemic Attack (TIA): Although less likely, a stroke or TIA could present with sudden loss of consciousness and must be considered due to the high risk of subsequent stroke if a TIA is missed.
  • Hypoglycemia: Especially in diabetic patients, hypoglycemia can cause confusion, loss of consciousness, and falls, making it crucial to check blood glucose levels.
  • Subdural Hematoma or Other Intracranial Bleed: A fall could result in head trauma, leading to an intracranial bleed, which is a medical emergency requiring immediate intervention.

Rare Diagnoses

  • Subclavian Steal Syndrome: A rare condition where there is a reversal of blood flow in the vertebral artery due to stenosis or occlusion of the subclavian artery, potentially leading to syncope.
  • Pulmonary Embolism: Although less common as a cause of syncope, a pulmonary embolism could lead to sudden loss of consciousness, especially if it causes a significant blockage of the pulmonary arteries.

Workup and Plan

The workup should include:

  • ECG to evaluate for cardiac arrhythmias
  • Blood glucose to rule out hypoglycemia
  • Complete Blood Count (CBC) and basic metabolic panel to assess for anemia, infection, or electrolyte imbalances
  • Imaging studies such as a CT scan of the head if there's suspicion of head trauma or intracranial bleed
  • Echocardiogram to evaluate cardiac structure and function
  • Tilt table test if vasovagal syncope is suspected
  • Neurological evaluation to assess for signs of stroke or seizure

The plan would involve treating the underlying cause, preventing future falls, and possibly referring the patient to a cardiologist or neurologist for further evaluation and management.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.