Does pegloticase cause hyperglycemia?

From the Research

Pegloticase and Hyperglycemia

• There is no direct evidence in the provided studies that pegloticase causes hyperglycemia 1, 2, 3, 4, 5.
• The studies primarily focus on the efficacy and safety of pegloticase in treating chronic gout, including its ability to lower serum urate levels, reduce gout flares, and improve quality of life.
• Adverse events reported in the studies include gout flares, infusion reactions, anaphylaxis, and exacerbation of pre-existing congestive heart failure, but hyperglycemia is not mentioned as a common adverse event 1, 2, 4.
• One study mentions that patients with glucose-6-phosphate dehydrogenase deficiency were excluded from the trial, but this is not directly related to pegloticase causing hyperglycemia 4.