From the Research
Yes, cefuroxime is available under several brand names, with Zinacef and Ceftin being the most common, as reported in various studies 1, 2, 3, 4, 5.
Overview of Cefuroxime
Cefuroxime is a second-generation cephalosporin antibiotic used to treat various bacterial infections including respiratory tract infections, urinary tract infections, skin infections, and Lyme disease.
Brand Names and Formulations
Zinacef is the brand name for the injectable form of cefuroxime, while Ceftin is the brand name for the oral formulation. The oral formulation is available as cefuroxime axetil, which is a prodrug of cefuroxime, as described in a study published in the International Journal of Antimicrobial Agents 1.
Dosage and Administration
The typical adult oral dose ranges from 250-500 mg twice daily, while injectable doses vary based on infection severity. Patients should be aware that cefuroxime oral tablets should be taken with food to enhance absorption, and the full prescribed course should be completed even if symptoms improve before finishing the medication, as recommended in a review of cefuroxime axetil 3.
Mechanism of Action and Side Effects
The medication works by interfering with bacterial cell wall synthesis, causing bacterial cell death. Side effects may include diarrhea, nausea, and allergic reactions, particularly in those with penicillin allergies due to potential cross-reactivity, as noted in several studies 1, 2, 4.
Efficacy and Safety
Cefuroxime axetil has been shown to be effective in the treatment of various infections, including community-acquired pneumonia, acute bronchitis, and skin and soft tissue infections, as demonstrated in clinical trials 3, 5. The drug is generally well tolerated, with most adverse events being mild to moderate in intensity and reversible upon discontinuation of treatment, as reported in a review of cefuroxime axetil 3.