What is the clinical efficacy of Nutrafol (saw palmetto, biotin, and other nutrients)?

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Last updated: May 6, 2025 • View editorial policy

From the Guidelines

Nutrafol has limited clinical efficacy for improving hair growth and reducing hair loss, primarily due to the lack of robust studies evaluating its singular effectiveness. The available evidence on Nutrafol's ingredients suggests that biotin, one of its components, may play a role in hair health, as biotin deficiency can lead to hair loss 1. However, the study by Camacho et al., mentioned in the context of alopecia areata, combined biotin with other treatments, making it difficult to assess biotin's independent efficacy 1. Key points to consider about Nutrafol include:

  • The supplement contains a blend of ingredients aimed at addressing multiple factors affecting hair health, such as inflammation, stress, and nutritional deficiencies.
  • Ingredients like saw palmetto may help block DHT, a hormone linked to hair loss, while ashwagandha may reduce stress-related hair shedding.
  • Marine collagen in the formula provides building blocks for hair structure, potentially improving hair thickness and quality.
  • Clinical efficacy may vary between individuals, with Nutrafol possibly being more effective for early to moderate hair thinning rather than advanced hair loss.
  • Users should be aware that consistent daily use for at least 6 months is recommended to properly evaluate the supplement's efficacy, and it is generally well-tolerated, although mild digestive discomfort may occur in some users.

From the Research

Clinical Efficacy of Nutrafol

  • The clinical efficacy of Nutrafol has been studied in several randomized, double-blind, placebo-controlled trials 2, 3.
  • A 6-month study published in the Journal of Drugs in Dermatology found that daily intake of Nutrafol Women's Balance Capsules resulted in a significant increase in terminal and total hair counts compared to placebo 2.
  • Another 6-month study published in the same journal found that Nutrafol Women's Capsules promoted hair growth and improved hair quality in women with self-perceived thinning hair 3.
  • The studies suggest that Nutrafol is a safe and effective treatment for promoting hair growth in women with thinning hair 2, 3.
  • However, the evidence for Nutrafol's efficacy in men is limited, and more studies are needed to fully understand its effects in this population.
  • Other treatments for androgenetic alopecia, such as minoxidil, finasteride, and low-level laser therapy, have also been shown to be effective in promoting hair growth 4, 5, 6.
  • A systematic review and meta-analysis published in the Journal of the American Academy of Dermatology found that minoxidil, finasteride, and low-level laser light therapy were all superior to placebo in promoting hair growth in men with androgenetic alopecia 6.
  • A network meta-analysis published in the Journal of Dermatological Treatment found that low-level laser therapy and minoxidil were among the most effective treatments for androgenetic alopecia in women 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.