From the FDA Drug Label
Riluzole tablets is indicated for the treatment of amyotrophic lateral sclerosis (ALS)
- Riluzole is a medication given for Amyotrophic Lateral Sclerosis (ALS)
- The recommended dosage is 50 mg twice daily 1
From the Research
Medications for Amyotrophic Lateral Sclerosis (ALS)
The following medications are used to treat ALS:
- Riluzole: a neuroprotective agent that has been shown to prolong survival and slow disease progression in patients with ALS 2, 3, 4, 5
- Edaravone: a medication that has been approved to slow disease progression in ALS patients 6, 4
- Sodium phenylbutyrate and taurursodiol (PB/TURSO): a combination medication that has been conditionally approved to slow disease progression and prolong survival in ALS patients 6, 4
- Tofersen: a medication that has been recently approved under accelerated approval and is contingent upon verification of clinical benefit in confirmatory trials 6
Disease-Modifying Treatments
There are currently four disease-modifying treatments approved for ALS:
- Riluzole
- Edaravone
- Sodium phenylbutyrate and taurursodiol (PB/TURSO)
- Tofersen 6
Symptomatic Treatments
Symptomatic treatments are used to manage common symptoms of ALS, including:
- Anxiety
- Depression
- Emotional lability (pseudobulbar affect)
- Fasciculations
- Fatigue
- Insomnia
- Muscle cramps or spasms
- Musculoskeletal pain due to immobility
- Neuropathic type pain
- Excessive salivation (sialorrhea)
- Spasticity
- Constipation
- Urinary urgency 6