From the FDA Drug Label
Riluzole tablets is indicated for the treatment of amyotrophic lateral sclerosis (ALS) Riluzole tablets is indicated for the treatment of amyotrophic lateral sclerosis (ALS) Riluzole tablets is indicated for the treatment of amyotrophic lateral sclerosis (ALS)
The medication given for Amyotrophic Lateral Sclerosis (ALS) is Riluzole 1, 1, 1.
From the Research
Medications for Amyotrophic Lateral Sclerosis (ALS)
The following medications are used to manage ALS:
- Riluzole: a neuroprotective agent that reduces damage to motor neurons by inhibiting glutamate release 2, 3, 4, 5
- Edaravone: a neuroprotective agent that prevents oxidative stress damage as a free radical scavenger 2, 6, 3, 4
- Sodium phenylbutyrate and taurursodiol (PB/TURSO): a disease-modifying treatment that slows progression of ALS 6, 3
- Tofersen: a recently approved therapy under accelerated approval, contingent upon verification of clinical benefit in confirmatory trials 6
Symptomatic Treatments
In addition to disease-modifying treatments, various medications are used to manage symptoms of ALS, including:
- Anxiety and depression
- Emotional lability (pseudobulbar affect)
- Fasciculations
- Fatigue
- Insomnia
- Muscle cramps or spasms
- Musculoskeletal pain due to immobility
- Neuropathic type pain
- Excessive salivation (sialorrhea)
- Spasticity
- Constipation
- Urinary urgency 6