From the Guidelines
The brand name for the amlodipine and benazepril combination medication is Lotrel, as indicated in the seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure 1. This combination drug is used to treat high blood pressure (hypertension) and contains two active ingredients: amlodipine, which is a calcium channel blocker that relaxes blood vessels, and benazepril, which is an ACE inhibitor that prevents the formation of a hormone that narrows blood vessels.
- The medication comes in various strengths, including 2.5/10 mg, 5/10 mg, 5/20 mg, 10/20 mg, as listed in the study 1.
- The combination of amlodipine and benazepril has been shown to be effective in lowering blood pressure and reducing the risk of cardiovascular events, as demonstrated in the ACCOMPLISH trial 1.
- Common side effects may include dizziness, swelling in the ankles or feet, headache, and cough.
- It's essential to take this medication regularly and continue it even if you feel well, as hypertension often has no symptoms.
- The ACCOMPLISH trial also found that the combination of benazepril and amlodipine was more effective than benazepril and hydrochlorothiazide in reducing the risk of cardiovascular events, with an absolute risk reduction of 2.2% (HR, 0.80; 95% CI, 0.72–0.90; P<0.001) 1.
From the Research
Amlodipine Benazepril Combination
- The brand name for the amlodipine benazepril combination is Lotrel 2.
- Lotrel is a fixed-dose combination product indicated for the treatment of hypertension 2.
- The combination of amlodipine and benazepril has been shown to be effective in reducing blood pressure in patients with hypertension 3, 4.
- Studies have demonstrated that amlodipine/benazepril is noninferior to other combination therapies, such as valsartan/hydrochlorothiazide, in terms of blood pressure reduction 3.
- The amlodipine/benazepril combination has also been shown to have beneficial effects on renal function, glucose control, and lipid profiles compared to other combination therapies 3.
- Fixed-dose combination therapy with amlodipine/benazepril has been found to improve blood pressure control and reduce the incidence of edema in patients with mild to moderate essential hypertension 4.