Can NyQuil (acetaminophen, dextromethorphan, and doxylamine) be taken with Sudafed (pseudoephedrine)?

It is generally not recommended to take NyQuil and Sudafed together without consulting a healthcare provider first. These medications contain different active ingredients that may overlap or interact. NyQuil typically contains acetaminophen, dextromethorphan, and an antihistamine, while Sudafed contains pseudoephedrine or phenylephrine. Taking both could lead to excessive decongestant effects, increased blood pressure, or potential overstimulation of the central nervous system. Additionally, you might inadvertently double-dose on certain ingredients if both products contain similar components. If you're experiencing multiple cold or flu symptoms, it's better to choose a single product that targets your specific symptoms or ask a pharmacist about safe combinations. Always check the active ingredients in each medication and be particularly cautious if you have underlying health conditions like high blood pressure, heart disease, diabetes, or thyroid disorders, as these medications may affect these conditions.