From the FDA Drug Label
Letrozole tablets are taken orally without regard to meals DOSAGE AND ADMINISTRATION Letrozole tablets are taken orally without regard to meals ( 2): Recommended dose: 2.5 mg once daily ( 2.1) The recommended dose of Letrozole tablets is one 2.5 mg tablet administered once a day, without regard to meals.
Administration of Letrozole: Letrozole can be taken without regard to meals. This means that it can be taken before or after food, as food does not affect its administration. 1, 1, 1
From the Research
Letrozole can be taken either before or after food, as food does not significantly affect its absorption. It is typically taken once daily at approximately the same time each day to maintain consistent blood levels. The standard dose is usually 2.5 mg once daily, though this may vary based on your specific condition and doctor's instructions. If you experience stomach upset, taking it with food might help reduce this side effect. Letrozole works by decreasing the amount of estrogen produced in the body by blocking the enzyme aromatase, which converts androgens to estrogens. This mechanism is particularly important in treating hormone-receptor-positive breast cancer in postmenopausal women or for fertility treatments.
Some key points to consider when taking letrozole include:
- Taking the medication at the same time each day to maintain consistent blood levels 2
- Being aware of potential side effects, such as stomach upset, and taking the medication with food if necessary 2
- Understanding the importance of letrozole in treating hormone-receptor-positive breast cancer in postmenopausal women 3
- Recognizing that letrozole has been shown to be effective in comparison to other treatments, such as tamoxifen 4
It's also important to note that if you miss a dose, you should take it as soon as you remember, but if it's almost time for your next dose, you should skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for a missed one. Overall, letrozole is an effective treatment for hormone-receptor-positive breast cancer in postmenopausal women, and taking it as directed can help to improve treatment outcomes.