Which enterotype produces hydrogen sulfide?

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Last updated: February 18, 2025View editorial policy

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From the Guidelines

The enterotype that produces hydrogen sulfide is characterized by a high abundance of sulfate-reducing bacteria, such as Desulfovibrio.

Key Characteristics

  • This enterotype is associated with the fermentation of sulfur-containing amino acids, which are found in high protein foods such as meats 1.
  • The production of hydrogen sulfide (H2S) has been proposed to contribute to bowel inflammation through various mechanisms, including impaired utilization of short-chain fatty acids and direct toxic effects 1.
  • However, other research suggests that H2S may have anti-inflammatory properties and contribute to mucosal healing 1.

Associated Bacteria

  • Desulfovibrio is a key bacterium involved in the production of hydrogen sulfide through the fermentation of sulfur-containing amino acids 1.
  • Other sulfate-reducing bacteria may also contribute to the production of hydrogen sulfide in this enterotype.

Dietary Associations

  • A diet high in red and processed meats may promote the growth of sulfate-reducing bacteria and increase the production of hydrogen sulfide 1.
  • In contrast, a diet high in fiber and low in fat may promote the growth of beneficial bacteria and reduce the production of hydrogen sulfide 1.

From the Research

Enterotypes and Hydrogen Sulfide Production

  • The enterotype that produces hydrogen sulfide is not directly mentioned in the provided studies 2, 3.
  • However, the studies suggest that sulfate-reducing bacteria (SRB) are responsible for sulfide production 2, 3.
  • SRB are found in the gut and are known to produce hydrogen sulfide as a byproduct of their metabolism 2.
  • The studies do not specifically identify which enterotype is associated with SRB, but they do provide information on the conditions that affect sulfide production by SRB 2, 3.
  • For example, the addition of nitrate can decrease net sulfide production rates by increasing sulfide oxidation rates 3.
  • The studies also suggest that the functional vertical structure of the biofilm can change in response to nitrate addition, leading to changes in sulfide production rates 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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