From the Research
Normal DHEA levels vary by age and gender, with adult men typically ranging from 100-400 μg/dL and adult women ranging from 50-350 μg/dL. These levels naturally peak in early adulthood and gradually decline with age, decreasing by about 10% per decade 1. DHEA is produced primarily by the adrenal glands and serves as a precursor to both male and female sex hormones. Abnormally high levels may indicate adrenal tumors or congenital adrenal hyperplasia, while low levels can occur with adrenal insufficiency or aging.
Key Points to Consider
- DHEA levels decline with age, with significant decreases by age 70-80 2
- DHEA replacement has been shown to have beneficial effects on bone mineral density, body composition, and psychological well-being in patients with adrenal insufficiency 3, 4, 2
- However, the role of DHEA replacement in standard treatment for adrenal insufficiency remains unclear, with inconsistent data and a need for further research 1
- If concerned about DHEA levels, a blood test ordered by a healthcare provider can measure DHEA sulfate, which provides a more stable assessment than measuring DHEA directly.
Important Considerations for DHEA Replacement
- DHEA replacement may be considered for patients with adrenal insufficiency, particularly those with low DHEA levels and symptoms such as fatigue, decreased libido, or decreased well-being 3, 4
- The optimal dose and duration of DHEA replacement are not well established, with studies using varying doses and treatment durations 3, 4, 2
- Further research is needed to fully understand the effects of DHEA replacement on morbidity, mortality, and quality of life in patients with adrenal insufficiency 1.