From the FDA Drug Label
To ensure proper dosing, the dose should be titrated based on the pre-dose morning serum testosterone concentration from a single blood draw at approximately 14 days and 28 days after starting treatment or following dose adjustment. In addition, serum testosterone concentration should be assessed periodically thereafter
The patient should have blood work done at approximately 14 days and 28 days after starting treatment or following dose adjustment, and then periodically thereafter to assess serum testosterone concentration and ensure proper dosing of testosterone gel 1.62% 1.
From the Research
Blood work should be done before starting Natesto and then monitored at 3-4 months after beginning treatment, followed by every 6-12 months thereafter if levels are stable, as supported by the most recent study 2.
Monitoring Schedule
The primary tests include:
- Total testosterone levels (ideally drawn 1-2 hours after a Natesto dose for peak levels)
- Complete blood count to check for elevated red blood cell counts
- Lipid profiles to monitor cholesterol Additionally, prostate-specific antigen (PSA) should be checked in men over 40 to monitor for prostate changes.
Adjusting the Schedule
Your doctor may adjust this schedule based on your individual response to treatment, any side effects you experience, or if you have underlying health conditions like cardiovascular disease or liver problems. More frequent monitoring may be needed if your dose is changed or if abnormalities are detected.
Importance of Monitoring
Regular monitoring is essential because testosterone therapy can affect multiple body systems, including blood cell production, cholesterol levels, and prostate health, as noted in studies 3, 4.
Considerations
Other studies have highlighted the importance of monitoring liver function, kidney function, and lipid profiles in patients with various health conditions 5, 6, but the most relevant guidance for Natesto comes from the study focused on its use 2.